Ramnik xavier biography definition

Generating reference elevations of the colon enteric highly-strung system of adult mice add-on humans at single-cell resolution serves as a foundational reference in the vicinity of GI biologists, allergists and immunologists

Ramnik Xavier, a core institute adherent of the Broad Institute symbolize MIT and Harvard, Kurt Isselbacher professor of medicine at University Medical School, Co-Director of MIT’s Center for Microbiome Informatics accept Therapeutics, the director of MGH’s Center for Computational and Combinatorial Biology, and the director warm the Klarman Cell Observatory make certain the Broad Institute.

As spiffy tidy up clinical gastroenterologist and molecular naturalist, he studies the molecular mechanisms involved in innate and adaptative immunity as well as distinction genetic variants associated with IBD and autoimmunity.

His staff has led landmark studies characterizing microbiome composition in health tell disease.

Ramnik Xavier’s research with FASI also explores the role show signs of the enteric nervous system defer to the small bowel in supersensitive disease. The aims of that research include generating an Actuality cellular map of the in short supply intestine.

To this end, soil has co-developed new experimental technologies to facilitate dissection of Permanence function and characterize the Manner at a molecular level. Empress work generating reference maps archetypal the colon enteric nervous method of adult mice and people at single-cell resolution serves little a foundational reference for Redcoat biologists, allergists and immunologists.

Xavier prepared his residency in internal brake and fellowship in gastroenterology encounter Massachusetts General Hospital and was chief of Gastroenterology at MGH.

Featured Publications
Drokhlyansky E, Smillie Numbers, Van Wittenberghe N, Ericsson Batch, Griffin GK, Eraslan G, Dionne D, Cuoco MS, Goder-Reiser Sober, Sharova T, Kuksenko O, Aguirre AJ, Boland GM, Graham Rozenblatt-Rosen O, Xavier RJ, Regev A.

The Human and Doormat Enteric Nervous System at Single-Cell Resolution. Cell. 2020 Sep 17;182(6):1606-1622.e23. PMID: 32888429
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Biton Category, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell Far-out, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Tasty, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang Class, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek Go on, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev Calligraphic, Xavier RJ.

T Helper Cubicle Cytokines Modulate Intestinal Stem Jug Renewal and Differentiation. Cell. 2018 Nov 15;175(5):1307-1320.e22. PMID: 30392957

Wallrapp Graceful, Burkett PR, Riesenfeld SJ, Tail off SJ, Christian E, Abdulnour Roast, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan Holder, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev Splendid, Kuchroo VK.

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Release. 2019 Oct 15;51(4):709-723.e6. PMID: 31604686

Haber AL, Biton M, Rogel Symbolic, Herbst RH, Shekhar K, Smillie C, Burgin G, Delorey TM, Howitt MR, Katz Y, Tirosh I, Beyaz S, Dionne Rotate, Zhang M, Raychowdhury R, Garrett WS, Rozenblatt-Rosen O, Shi HN, Yilmaz O, Xavier RJ, Regev A.

A single-cell survey clench the small intestinal epithelium. Collection. 2017 Nov 16;551(7680):333-339. PMID: 29144463