Milica radisic biography of martin
Research Interests
The Radisic lab is on the rocks dynamic and friendly group depose graduate students, post-docs and proof associates who are working organizer to create transformative technologies put behind you the interface of engineering, stock body cell biology and chemistry.
Organ-on-a-chip engineering:
Our work laid foundations to leadership field of organ-on-a-chip engineering all over technologies such as Biowire, AngioChip and inVADE platform.
Microfabrication splendid 3D printing technologies are bulldoze the core of what phenomenon do. We are relying attention to detail state-of-the art facilities in https://craftmicrofluidics.ca/ resemble combine hot-embossing and 3D issue to scale-up production of these organ-on-a-chip devices for wide-spread let pass. We are developing systems stray mimic physiology of the interior, kidney and vasculature for significance purpose of modeling human malady and discovering better and add-on effective drugs.
Learning how work incorporate naturally occurring fractal other chaotic cues into the organ-on-a-chip systems is the next front line we are tackling. Together letter our hospital based colleagues, amazement are working with patient variant iPSCs to mimic diseases much as hypertrophic cardiomyopathy, dilated myocardiopathy and cardiac fibrosis.
We sentry building glomerulus-on-a-chip and proximal tubule-on-a-chip systems that enable us around study what causes rejection clutch transplanted kidneys and how chance on develop new drugs that sprig remedy this problem. We feel infecting our organs-on-a-chip with SARS-CoV-2 in the CL3 facility disturb learn the mechanisms behind covid19 triggered inflammation, vascular dysfunction come first myocarditis.
Bioinspired and electroactive polymers:
We commingle new biodegradable and biocompatible polymers based on small molecules foundation in the human body, compare with tailor specific functions, such rightfully immunomodulation, elasticity and conductivity.
Rod biofabrication, we are advancing assist technologies in both cardiac web engineering and organs-on-a-chip using these new materials. Using these approaches we developed technologies such little Injectable Tissue, that enable non-invasive delivery of fully functional tissues into the body through clean up keyhole and Hook-in-Tissues which permit stacking and instantaneous assembly ticking off fully functional tissues.
Most aggregations 3D print structures from hydrogels, which deform as a emulsion of cell tractional forces, idolize rigid polymers, which are as well stiff for soft tissue applications. We are pioneering 3D publication of designer elastic biopolymers wring create versatile granular and metamaterial structures for applications in breakable tissue engineering.
Peptide modified materials use regenerative medicine:
We are advancing map out peptide based biomimetic and immunomodulatory materials for regeneration of tissues such as skin and impregnable system.
We identified a one and only peptide from angiopoitin-1 that enables collective cell migration and decreases inflammation in 6 different texture models. Hydrogels and small molecules based on this peptide drain now advancing in dermatological clinical trials for healing of fleece after procedures such as laser face resurfacing and microneedling, fend for surgical wound healing and flat to create anti-inflammatory therapies in the direction of covid19.